General description

A cell-permeable thiazolidinedione compound that acts as a potent, ATP-competitive, and isoform-selctive PI 3-K inhibitor (IC₅₀ = 0.07, 0.24, 1.45, and 1.70 M for the γ, α, β, and δ isoform, respectively) with little or no activity against a panel of 38 other commonly studied kinases (﹤20% inhibition at 1.0 M). Exhibits similar pharmacokinetics as LY 294002 in blocking rhRNATES-induced neutrophil peritoneal recruitment in mice in vivo. Also reported to exhibit significant in vivo prophylactic efficacy against carrageenan-induced tissue swelling in a rat paw edema model (100 mg/kg, p.o.).

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Ferrandi, C., et al. 2007. J. Pharmacol. Exp. Ther.322, 923.

Packaging

Packaged under inert gas

5 mg in Plastic ampoule

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Warning

Toxicity: Irritant (B)